Axonal transport, degeneration, and regeneration in the visual system of the goldfish

by Hartwig Wolburg

Publisher: Springer-Verlag in Berlin, New York

Written in English
Published: Pages: 94 Downloads: 426
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  • Visual pathways.,
  • Axonal transport.,
  • Nervous system -- Degeneration.,
  • Nervous system -- Regeneration.,
  • Goldfish -- Physiology.

Edition Notes

StatementHartwig Wolburg.
SeriesAdvances in anatomy, embryology, and cell biology ;, v. 67
LC ClassificationsQL801 .E67 vol. 67, QP475 .E67 vol. 67
The Physical Object
Paginationix, 94 p. :
Number of Pages94
ID Numbers
Open LibraryOL4107923M
ISBN 100387103368
LC Control Number80022731

Bernice Graftstein Shanet (born Septem ) is a Canadian neurophysiologist, a professor at Weill Cornell Medical College in New York and a noted specialist in neuroregeneration research. Shanet is a Professor of Physiology and Biophysics at Weill Cornell Medical College, the holder of the Vincent and Brooke Astor Distinguished Professorship in Neuroscience at Weill Cornell Medical. The motor axon sprouts, if lucky a sprout will find an array of Schwann cells/ ECM to guide its growth. When the motor axon contacts a muscle, retrograde signals change gene expression to allow it to function as a transmitting neuron again. sprout Reaches muscle and forms a synapse, schwaan cells start to myeinat axon. index of gliogenesis related to axonal regeneration or degenerat and its size, as an index of fiber loss. For additional insight into the specificity of the trophic effect of retinal afferents on TGZ, I looked for experimental effects on the size and mitotic activity of the torus longitudinalis (TL). maintenance of nervous system structure over time Axonal degeneration can occur as a result of nerve injury or through the disruption of neuronal maintenance mechanisms, and is a hallmark of neurodegenerative disorders such as motor neuron, Alzheimer’s, Parkinson’s, and .

(). Myelin debris clearance during Wallerian degeneration in the goldfish visual system. (). Neuronal cell proliferation and ocular enlargement in Black Moor goldfish. (). Ocular manifestations of DonnaiBarrow syndrome. (). Organization of astrocytes in the visual pathways of the goldfish: an immunohistochemical study. (). The goldfish visual system has been extensively used in biochemical, electro- physiological, anatomical and behavioral studies 3,Ta°,n,lB,19, as well as in those con- cerned with neuronal plasticity and regeneration 4,6. Conventional silver-degeneration. After a traumatic injury of the nervous system or in the course of a neurodegenerative disease, the speed of axonal regeneration and the control of the inflammatory response are fundamental parameters of functional recovery. Spontaneous regeneration takes place in the peripheral ner-vous system, although the process is slow and often incomplete. Axonal transport, degeneration, and regeneration in the visual system of the goldfish Wolberg, Wolberg Antibodies to neurofilament, glial filament and fibroblast intermediate filament proteins bind to different cell types of the nervous system.

Fast axonal transport of kinesin in the rat visual system: functionality of the kinesin heavy chain isoforms. Molecular Biology of the Cell, 6, 21 Griffin, J. W., George, E. B., Hsieh, S., & Glass, J. D. (). Axonal degeneration and disorders of the axonal cytoskeleton. In S Axonal transport defects in neurodegenerative diseases. This chapter discusses cytoskeletal changes in axonal degeneration. It begins with a review of the organization of the normal axonal cytoskeleton, followed by a summary of the current understanding of Wallerian degeneration. It then considers the slowly evolving axonal degenerations in which alterations in neurofilament content are an early aspect, and their pathophysiology is assessed in. Olig2-Induced Semaphorin Expression Drives Corticospinal Axon Retraction After Spinal Cord Injury Cereb Cortex. Jun 22;bhaa doi: /cercor/bhaa Molecules that are found in the extracellular environment at a CNS lesion site, or that are associated with myelin, inhibit axon growth. In addition, neuronal changes—such as an age-dependent reduction in concentrations of cyclic AMP— render the neuron less able to respond to axotomy by a rapid, forward, actin-dependent movement. An alternative mechanism, based on the protrusive forces.

Axonal transport, degeneration, and regeneration in the visual system of the goldfish by Hartwig Wolburg Download PDF EPUB FB2

1 Introduction.- 2 Material and Methods.- 3 Results.- Morphology of the Goldfish Visual System.- Retina.- Optic Nerve and Optic Tract.- Optic Tectum.- Axonal Transport.- Rapid Axonal Transport.- Effect of Ouabain on Rapid Transport.- In Vitro Investigations of Rapid Axonal Transport.- Slow.

Axonal Transport, Degeneration, and Regeneration in the Visual System of the Goldfish (Advances in Anatomy, Embryology and Cell Biology): Medicine & Health Science Books @ ed by: Axonal transport, degeneration, and regeneration in and regeneration in the visual system of the goldfish book visual system of the goldfish.

Wolburg H. Advances in Anatomy, Embryology, and Cell The effect of inhibition of axonal RNA transport on the restoration of retinotectal projections in regenerating optic nerves of goldfish. The Book of Longings.

Sue Monk Kidd. € €. General Features of the Goldfish Visual System. Like the brain and the spinal cord, the visual system of the vertebrates is a component of the central nervous system (CNS). In the goldfish, the visual system is made up of three distinct compartments (Figure 1).

(1) The retina, which lines the posterior of the eye. Biochemical Aspects of the Regenerating Goldfish Visual System. Bernard W. Agranoff, Thomas S. Ford-Holevinski. Effect of a Conditioning Lesion on Axonal Transport During Regeneration. Irvine G. McQuarrie.

It appears timely to review the role played by axonal transport in the intrinsic responses of neurons in the growth and regrowth. Biochemical Aspects of the Regenerating Goldfish Visual System. Pages Target-Dependent and Target-Independent Changes in Rapid Axonal Transport During Regeneration of the Goldfish Retinotectal Pathway.

The Relationship of Slow Axonal Flow to Nerve Elongation and Degeneration. 1. Introduction. When the optic nerve of the goldfish sustains a crushing injury, the severed retinal ganglion cell axons regenerate and re-establish functional connections in the is similar to the response seen in the mammalian peripheral nervous system (PNS) following axon stingly, regeneration in the PNS is associated with a massive invasion of the distal nerve.

Wolburg transport, degeneration, and regeneration in the visual system of the goldfish Advances in Anatomy, Embryology and Cell Biology, Vol. 67, Springer-Verlag, Amsterdam () Google Scholar. Abstract. Changes in axonally transported phospholipids of regenerating goldfish optic nerve were studied by intraocular injection of [ H]glycerol 9 days and 16 days after nerve crush at 30° four major glycerophospholipids all showed substantial increases in transported radioactivity above non-regenerating controls at both time points, these being maximal ( to fold) in the optic.

All these findings in the visual system are translatable to the CNS as a whole and thus strategies that successfully promote visual axon regeneration will be equally effective elsewhere in the CNS.

Vidal-Sanz M, Bray GM, Villegas-Perez MP, Thanos S, Aguayo AJ. Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat. J Neurosci. ;– Wolburg H. Axonal transport, degeneration, and regeneration in the visual system of the goldfish.

Adv Anat Embryol Cell Biol. ; Axonal transport, degeneration, and regeneration in the visual system of the goldfish. Wolburg H. Author(s): Wolburg,Hartwig, Title(s): Axonal transport, degeneration, and regeneration in the visual system of the goldfish/ Hartwig Wolburg.

Country of Publication: Germany Publisher: Berlin ; New York: Springer-Verlag, Figure Axon regeneration and degeneration in response to acute and chronic injuries.

(A) Acute injuries physically break axons into two parts: a proximal stump, which remains connected to the cell body, and a distal stump, which has lost this many cases the distal stump has presynaptic terminals (cartooned as button-shaped boutons) that are made nonfunctional by the injury.

Request PDF | Axonal Degeneration and Regeneration in the Peripheral and Central Nervous Systems | This chapter presents an overview of basic principles related to neuronal responses to injury and. Regeneration in the Goldfish Visual System. Sam Nona Wolburg, H.

() Axonal transport, degeneration and regeneration in the visual system of the goldfish. Anat. Embryol. Cell Biol. The author Dr Sam (Shmaiel) Nona was born in Northern Mesopotamia (now Iraq).

At the age of 17 he gained a scholarship to study in England. Axonal transport, also called axoplasmic transport or axoplasmic flow, is a cellular process responsible for movement of mitochondria, lipids, synaptic vesicles, proteins, and other organelles to and from a neurons cell body, through the cytoplasm of its axon called the axoplasm.

Since some axons are on the order of meters long, neurons cannot rely on diffusion to carry products of the nucleus. Numerous optic nerve fibers persist for a period of up to 20 months following enucleation in reptiles, although it is unlikely that a significant number of efferent fibers are present.

After varying. The time course of Wallerian degeneration in the tibial and saphenous nerves was compared in Balb/c mice and mice of the C57BL/Ola strain (Lunn et al., ). Axons, particularly myelinated ones, in. ISBN: OCLC Number: Description: xvi, pages: illustrations ; 24 cm.

Contents: Axoplasmic transport in relation to nerve fiber regeneration / Sidney Ochs --Basic properties of fast axonal transport and the role of fast transport in axonal growth / Scott T.

Brady --Retrograde signaling after nerve injury / Krister Kristensson --Retrograde axonal transport. The book Axonal Regeneration in the Central Nervous System is the book to have for those interested in spinal cord injury and axonal regeneration in general.

Eventually, perhaps 50 years from now, this book may become the framework for a Foreword of a new book, documenting the important steps and the thinking that led to Superman really walking.

Fagiolini M, Caleo M, Strettoi E, Maffei L. Axonal transport blockade in the neonatal rat optic nerve induces limited retinal ganglion cell death.

J Neurosci;– Fawcett JW. Astrocytic and neuronal factors affecting axon regeneration in the damaged central nervous system. Cell Tissue Res. ;–   A novel 3′-UTR element mediates axonal transport of role for S1P signalling in axon guidance in the Xenopus visual system. leads to mitochondrial dysfunction and axon degeneration.

Recent studies show that axon degeneration precedes, and sometimes causes, neuronal death in several disorders 1,2,3,4,5, so the need to understand its mechanisms is is a. -Axonal transport is for proteins to be shipped down the axon using microtubules -Rate of regeneration is 1 to 5 mm/day; slow axonal transport.

Degeneration events in the nervous system. Terminal degeneration 2. Wallerian degeneration of distal segment 3. Myelin debris. axonal degeneration: a type of peripheral nerve fiber response to insult, wherein axon death and subsequent breakdown occur, with secondary breakdown of the myelin sheath associated; caused by focal injury to peripheral nerve fibers; often referred to as wallerian degeneration.

Synonym(s): axon degeneration. Keywords Axotomy, Axonal degeneration, Axonal regeneration, Axonal proteins, Spinal cord lesions, Recovery of function, Nerve plasticity Peters A, Palay S, Webster H de F. The fine structure of the nervous system. Traumatic injuries in the adult central nervous system (CNS) are often associated with permanent neurological impairments.

This is mainly due to the limited capacity of adult axons to regenerate and to the irreversible loss of neuronal cells [1,2].The model of rodent optic nerve injury has extensively been used to study the mechanisms responsible for the failure of axonal regeneration in the CNS.

Axonal transport deficits and degeneration can evolve independently in mouse models of amyotrophic lateral sclerosis Petar Marinkovic´ a, Miriam S. Reuter, Monika S.

Brilla, Leanne Godinhoa, Martin Kerschensteinerb,1,2, and Thomas Misgelda,c,d,1,2 aBiomolecular Sensors and Center for Integrated Protein Sciences (Munich) at the Institute of Neuroscience, Technische Universität München.

Axonal degeneration is a common feature of traumatic, ischemic, inflammatory, toxic, metabolic, genetic, and neurodegenerative disorders affecting the CNS and the peripheral nervous system (PNS).

The typical example is Wallerian degeneration (WD), which results from traumatic or ischemic injuries that disconnect the neuronal cell body from the distal segment of the axon.PATH60 Demonstration of the time course of retrograde trans-synaptic degeneration in the visual system using optical Dis Model Mech S2D).

No changes of retrograde mitochondrial axonal transport and no influence of NPTA on this Degeneration and Regeneration in the Nervous System.

Newark,NJ: Harwood Academic.• Neurons, glial cells, degeneration, regeneration, axonal transport • Review of the development of the human nervous system • Overview of the anatomy of the spinal cord, brain stem and forebrain • General sensory paths (pain, temperature, touch, pressure, proprioception).